Mpox Vaccination Frequently Asked Questions

Considering getting vaccinated for mpox but you live out of town? Here’s what you need to know:

Will the side effects make me feel as ill as the COVID vaccination did for some people?

Answer: No, for most individuals over the age of 18 with no preexisting health concerns that would prevent them from getting vaccinated, the most common side effect is general irritation at the injection site.

Between August 2022 and January 2023, the Biden Administration declared mpox a public health emergency, which allowed healthcare providers to administer the JYNNEOS vaccine via intradermal (under the skin) injections instead of the traditional subcutaneous (into the fat layer) method. This method was adopted to stretch the vaccine supply during the emergency.

Today, the vaccine supply is sufficient, and there is no longer a need to ration doses. The JYNNEOS vaccine is now administered subcutaneously under standard guidelines.

What to expect with the current vaccination method:

  • Injection Site: You may experience mild itching and a palpable bump at the injection site. These reactions are typically mild and resolve within a few weeks.
  • Systemic Reactions: Serious side effects are rare. Most people do not experience significant systemic symptoms like fever or fatigue.

How long does it take for the vaccine to become effective?

Answer: It generally takes about two weeks after the second dose of the JYNNEOS vaccine for your body to build maximum protection. The vaccine is given in two doses, spaced four weeks apart.

Is the JYNNEOS vaccine safe for people with weakened immune systems?

Answer: Yes, the JYNNEOS vaccine is a non-replicating vaccine, meaning it is safe for people with weakened immune systems, including those with HIV. However, it’s always best to consult with a healthcare provider about your specific health conditions before getting vaccinated.

Can I get vaccinated if I am currently sick?

Answer: If you are experiencing symptoms of Mpox or any other illness, it is recommended to wait until you have fully recovered before getting vaccinated. Consult with a healthcare provider for specific guidance based on your condition.

What should I do if I miss my second dose?

Answer: If you miss your second dose, it is important to reschedule it as soon as possible. You should still receive the second dose even if it is delayed. This will ensure you get the full protective benefits of the vaccine.

Where can I find more information about mpox and the JYNNEOS vaccine?

You can visit our Resources page for more information about mpox.